Warning: ini_set(): A session is active. You cannot change the session module's ini settings at this time in /home/assailry/public_html/lib/pkp/classes/session/SessionManager.inc.php on line 69

Warning: Cannot modify header information - headers already sent by (output started at /home/assailry/public_html/lib/pkp/classes/session/SessionManager.inc.php:69) in /home/assailry/public_html/plugins/generic/citationStyleLanguage/CitationStyleLanguagePlugin.inc.php on line 478

Warning: Cannot modify header information - headers already sent by (output started at /home/assailry/public_html/lib/pkp/classes/session/SessionManager.inc.php:69) in /home/assailry/public_html/plugins/generic/citationStyleLanguage/CitationStyleLanguagePlugin.inc.php on line 479
@article{Muhammad Ateeb*_Abid Hussain_Hafiz Muhammad Asif*_Rabia Zahid_Ali Raza Ayub_2026, title={Evaluation of Anticancer, Antioxidant and Anti-diabetic activity of Silver Nanoparticles using leaf extract of Grewia asiatica}, volume={5}, url={https://www.assajournal.com/index.php/36/article/view/1318}, abstractNote={<p><em>Diabetes and cancer are two severe, multifaceted, and long-lasting diseases.  Each year, diabetes mellitus and cancer claim the lives of about 11 million individuals. Recently, metal-based nanoparticles (MNPs), which were produced utilizing plant extracts in an ecologically benign way, have appeared as a superior choice for the management of these deadly illnesses. The current study investigated the antioxidant, anti-diabetic, and anticancer properties of greenly generated silver nanoparticles (AgNPs) and Grewia asiatica Linn (G. asiatica), a leaf extract from the Malvaceae family. The results indicate the color transition of the DPPH solution from purple to yellow, with the crude extracts exhibiting robust antioxidant activity (78.68% ± 0.02) and the nanoparticles demonstrating even higher activity (81.62% ± 0.02) against DPPH. Furthermore, with IC50 values of 177.3 μg/ml, 99.8 μg/ml, and 73 μg/ml, respectively, AgNPs efficiently prevent the development of human breast (MCF-7), cervical (HeLa), and liver (HepG2) cancer cells at exceptionally low doses. Additionally, the AgNPs exhibited superior anti-diabetic activity, as demonstrated by alpha-glucosidase and alpha-amylase inhibition assays (85.03% ± 0.02 and 75.15± 0.01 accordingly). AgNPs were therefore shown to be a potent α-glucosidase inhibitor, a free radical scavenger, and an efficient medicinal substance that targets human breast cancer cell lines (MCF-7). To determine the nanoparticles’ anticancer and antidiabetic actions, further research is necessary.</em></p> <p><strong><em>Keywords</em></strong><em>: Grewiaasiatica, alpha-amylase, alpha-glucosidase, MTT assay.</em></p>}, number={01}, journal={`}, author={Muhammad Ateeb* and Abid Hussain and Hafiz Muhammad Asif* and Rabia Zahid and Ali Raza Ayub}, year={2026}, month={Jan.}, pages={384–404} }